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Q: Do I have to compile Mesa with –enable-dri3 ?
A: it's not required and you may want not have it
Q: I have Intel card, can I test nine/st?
A: You'll need compile in i915g driver (for older Intel cards) or ilo. Don't expect it'll be flawless on these drivers.
Q: Why do I need compile Mesa first?
A: Mesa installs headers which are used by wine compilation