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Q: Do I have to compile Mesa with –enable-dri3?
A: It's not required and you may want not have it. DRI2 works but it is slower.
Q: I have an Intel card, can I test nine/st?
A: You'll need to compile the i915g driver (for older Intel cards) or ilo. Don't expect it to be flawless on these drivers.
Q: Why do I need to compile Mesa first?
A: Mesa installs headers which are used by wine compilation.
Q: Why do applications report a Geforce GTX 680, but I have a different card?
A: It's a hardcoded string at this moment, don't worry about it.